RAF Typhoon FGR4s have conducted a mission with France's air force in a joint strike targeting an underground arms cache in Syria operated by the IS group, according to the UK's MoD.
The location, identified by reconnaissance, was assessed as containing munitions and bombs, the announcement noted, and was positioned in mountainous terrain just to the north of the ancient city of Palmyra in central Syria.
"The RAF jets employed laser-guided Paveway IV weapons to target a series of approach shafts down to the depot... initial indications indicate the objective was successfully hit," officials stated.
There was no indication of any harm to civilians in the operation late on Saturday and all the aircraft made a safe return, the ministry further stated.
The British jets were assisted by a Voyager refuelling tanker.
IS - alternatively referred to as the so-called Islamic State - established extremist governance over parts of both Syria and Iraq prior to its 2019 collapse.
"This action underscores the UK's leading role, and resolve to stand shoulder to shoulder with our partners, to eradicate any resurgence of Daesh and their harmful and extremist ideologies in the Middle East," the British Defence Secretary the minister said.
RAF aircraft have performed overwatch operations over Syrian airspace to "prevent any attempted resurgence" of the group following its routing at the battle of Baghuz in the year 2019, the ministry said.
"I extend gratitude to the personnel of British forces participating in this mission for their professionalism and their courage," the Defence Secretary added. "They were part of thousands of British personnel stationed over the festive period. This mission, to eliminate dangerous terrorists who pose a risk to our safety, highlights how British military are always on standby, throughout the year, keeping Britain secure within its borders and powerful internationally."
In December, the US military conducted what it termed a "large-scale strike" targeting Islamic State objectives in Syria, following an ambush killed two American soldiers and a local interpreter in the Palmyra area.
The UN estimates Daesh still has roughly 5-7 thousand fighters in both countries.
